Figure 6: Characteristics and overlap of sites showing interaction between age or sex and genetic or environmental variance.
From: Genetic and environmental influences interact with age and sex in shaping the human methylome
(a) Venn diagram of the number of CpGs with significant interaction between sex and genetic variance (Sex × Va), between sex and unique environmental variance (Sex × Ve), between age and genetic variance (Age × Va) and between age and unique environmental variance (Age × Ve). (b) Density plot of CpGs with significant interaction effects. (c) Distribution of methylation sites with interaction effects relative to genes: DP, distal promoter; DS, downstream region; GB, gene body; IG, intergenic; PP, proximal promoter. (d) Distribution of methylation sites with interaction effects in relation to CpG density: CGI, CpG island; NC, non-CGI; SHE, CpG island shelf; SHO, CpG island shore. Asterisks denote significant enrichment or depletion (α=4.27 × 10−4, χ2-test). Results are based on data from 2,603 individuals.
