Figure 8: A proposed model of TGF-β in regulation of the Hippo pathway.
From: Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways
Hypoxia activates Siah2 and enhances the secretion of TGF-β. Zyxin functions as a scaffold protein that is upregulated in response to TGF-β stimuli, thus forming a ternary complex with Siah2 and Lats2, thereby facilitating Siah2-Lats2 binding and promoting Lats2 degradation and coordinately activation of Yap.
