Figure 2: Modification of complex molecules. | Nature Communications

Figure 2: Modification of complex molecules.

From: Practical carbon–carbon bond formation from olefins through nickel-catalyzed reductive olefin hydrocarbonation

Figure 2

(a) 10% NiBr2.diglyme, 15% L8, 3.0 equiv. DEMS, 3.0 equiv. Na2CO3, 2 ml DMAc, 30 °C, 12 h. (b) The same conditions as in a the newly formed carbon–carbon bond was between C10 and C11. (c) 20% NiBr2.diglyme, 30% L8, 3.0 equiv. DEMS, 3.0 equiv. Na2CO3, 2 ml DMAc, 30 °C, 12 h. (d) conditions for compound 44: 20% NiBr2.diglyme, 30% L8, 2.0 equiv. DEMS, 2.0 equiv. Na2CO3, 2 ml THF/DMAc (v/v=1/3), 30 °C, 12 h, the newly formed carbon–carbon bond was between C19 and C20; conditions for compound 47: same conditions as in c. (e) Same conditions as in c. (f) 20% NiBr2.diglyme, 30% L8, 4.0 equiv. DEMS, 4.0 equiv. Na2CO3, 2 ml DMAc, 30 °C, 12 h. Bn, benzyl; Bz, benzoyl; TMS, trimethylsilyl.

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