Figure 3: Histology of cardiac xenografts. | Nature Communications

Figure 3: Histology of cardiac xenografts.

From: Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

Figure 3

(a) Graft biopsy on day 182 (i) in baboon #210, demonstrating normal myocardial architecture; terminal histology of grafts from baboons #210 (ii, illustrating myocyte necrosis; #15009 (iii, showing focal myocarditis; and #110 (iv, showing myofibril loss with mineralization; × 400). (b) Baboon #910. Left panel shows normal histology of biopsy specimens obtained on days 196 (i), 350 (ii) and 567 (iii); right panel illustrates terminal histology, with multifocal fibrosis (iv), coagulative necrosis (v) and venular thrombi (vi). (c) Baboon #510. Left panel shows normal histology from biopsies on days 412 (i), 630 (ii) and 854 (iii). Middle and right panels show terminal graft histology, illustrating haemorrhage (iv), arteritis (v), coagulative necrosis (vi), neutrophilic infiltrates (vii), epicardial infiltrates (viii) and venular thrombi (ix). (d) Thrombomodulin expression in explanted grafts from baboons #510 and #910 by immunohistochemistry (IHC). Scale bar, 50 μm.

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