Figure 3: N8–5 complex.

(a) Superimposition of N8–inhibitor complexes of 3-allyl-Neu5Ac2en (5, green) and Neu5Ac2en (4, magenta; 2htr). (b) N8–5 complex with open 150-loop (5 in CPK format). The N8–5 complex maintains the open conformation of the 150-loop seen in the apo structure⁵ (a, b).