Figure 4: N8–6 complex.
From: Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase
(a) Superimposition of N8–inhibitor complexes of 3-(p-tolyl)allyl-Neu5Ac2en (6, cyan) and Neu5Ac2en (4, magenta; 2htr). (b) N8–6 complex with an open 150-loop (6 in CPK format). (c) N8–4 complex with a closed 150-loop5 (4 in CPK format). The N8–6 complex maintains an open conformation of the 150-loop seen in the apo structure5 (a, b), in contrast to the complex with 4 where the 150-loop is closed (c).
