Figure 1: Profiling of circular RNAs in human normal and cancerous tissues. | Nature Communications

Figure 1: Profiling of circular RNAs in human normal and cancerous tissues.

From: Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs

Figure 1

(a) The number of circRNAs and back-spliced reads identified in six human normal tissues and seven human cancerous tissues. (b) Genomic origin of human circRNAs. (c) The length distribution for exonic circRNAs (n=20,533, only known spliced length was considered). (d) Clustered heatmap for tissue-specific circRNAs from six human normal tissues, with rows representing circRNAs and columns representing tissues. The circRNAs were classified according to the Pearson correlation. The numerical data represented log10-transformed mean SRPBM of two replicates. (e) Violin plot of relative abundance of circRNAs in seven cancer tissues compared with the paired normal tissues. Data are expressed as the log2 foldchange of SRPBM. The white dot represents the median. (f) Numbers of specific circRNAs identified in seven cancerous and matched normal tissues. Cancer-specific circRNAs are shown in red. Normal specific circRNAs are shown in green.

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