Figure 1: Direct measurement of cell cycle kinetics.
From: 4D Visualization of replication foci in mammalian cells corresponding to individual replicons
(a) Patterns of PCNA distribution in all cell cycle stages imaged with live-cell time-lapse microscopy of human HeLa Kyoto (top) and mouse C2C12 cells (bottom). S-phase stages are further subdivided into early (Se) mid (Sm) and late (Sl). (b) Duration of the cell cycle phases (mean±s.d.; additional data in Table 1) measured from time-lapse microscopy analysis as shown in a (see also Supplementary Movie 1). Error bars represent s.d., number of replicates for human cells G1: 31, S: 30, G2: 27, M: 26; mouse cell replicates, G1: 20, S: 16, G2: 5, M: 10. Scale bar, 5 μm.
