Figure 7: Arthropoda diversify two systems to generate Dscam isoforms.
From: A large family of Dscam genes with tandemly arrayed 5′ cassettes in Chelicerata
Exons that are arranged in a tandem array or their orthologues are shown in coloured boxes, while the constitutive exons (CE) flanking the duplicated exons or their orthologues are shown in the black box. The introns are represented by the lines and are not drawn to scale. The emergence of internal tandem exon duplication is indicated by the filled squares. The emergence of 5′ cassette duplication is indicated by black line squares. The filled circle represents gene duplication. Extant organization of Dscam pre-mRNA and proposed ancestor molecules shown are associated with a cladogram of the phylogenetic relationships in this study26. Dscam1 in D. melanogaster, D. pulex and S. maritima are shown according to previous studies3,25,36. The analysed species and detailed sDscam data are shown in Fig. 1 and Supplementary Fig. 2. The number of copies is shown in parentheses.
