Figure 3: Insulin signalling-related genes are upregulated by TBP-2 deficiency in skeletal muscle.
From: Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity
The expression of insulin signal-related genes from the skeletal muscle of 10 weeks aged WT (white bar), TBP-2−/− (dark grey bar), ob/ob (black bar) and ob/ob·TBP-2−/− (light grey bar) mice. (a) Real-time PCR analyses were performed. Asterisk indicates *P<0.05 ;WT versus TBP-2−/−, WT versus ob/ob, ob/ob versus ob/ob·TBP-2−/−. (b) Immuno blotting (IB) analyses, n per group 3–5 each. Two U kg−1 insulin (+) or saline (−) was injected. Densitometric quantification of IRS-1/β-actin is shown in the bar graph. Data are presented as mean±s.d. *P<0.05, ***P<0.001, versus control (t-test).
