Figure 8: A model for metabolic function of TBP-2 in diabetes.
From: Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity
Role of TBP-2 in promoting obesity-induced type 2 diabetes. Environmental stresses including obesity cause upregulation of TBP-2. Sustained expression of TBP-2 may impair mitochondrial function and insulin secretion in β-cells and aggravate insulin resistance in skeletal muscle. Augmented expression of TBP-2 may also result in β-cell apoptosis. These changes lead to glucose intolerance and hyperglycaemia and obese-induced type 2 diabetes.
