Figure 2: Ring-closing alkyne metathesis on solid support. | Nature Communications

Figure 2: Ring-closing alkyne metathesis on solid support.

From: Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides

Figure 2

(a) Sequences of peptides 7–9 containing different macrocylic architectures. (b) Sequence of peptide 10 with non-natural amino acids 1 and 2 at position i and i+4 (nine-carbon crosslink) with corresponding chromatograms of crude reaction mixtures before (10, top) and after RCAM (11, middle) and after dibromination (12, bottom). Corresponding product peaks are highlighted: open (10, blue), closed (11, red) and dibrominated (12, orange) macrocycle. Chromatograms were obtained after deprotection and release of intermediates from the resin. ‘j’ represents Complex 5, dry toluene, 40 °C, 2 × 1.5 h; ‘k’ represents CuBr2, dry MeCN, 3 × 1 h.

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