Figure 2: Electrocardiograms and whole hearts from WT transgenic and E17K transgenic zebrafish.
From: A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation
(a) WT transgenics exhibit a regular heart rate with electrocardiogram parameters typical for adult zebrafish. E17K transgenics display significantly slower sino-atrial activity and increased heart rate irregularity compared with controls. (b) Signal-averaged P-wave duration is prolonged in E17K transgenics, indicative of slower atrial conduction time. (c) Atrial area has been traced in isolated whole-WT transgenic and -E17K transgenic hearts (dotted lines), showing enlarged atrial chamber size in E17K transgenic.
