Figure 5: Predicted interaction of Myl4 with putative actin-binding site.
From: A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation
(a) WT E11–Myl4 is in close proximity to K358 of actin and is predicted to form a stable electrostatic interaction between the negatively charged oxygen of E11 and positively charged nitrogen of actin K358 (b). (c) This electrostatic interaction within the actin-binding site is lost with substitution of positively charged K11. Dark-blue sphere, positively charged nitrogen molecule. Red sphere, negatively charged oxygen molecule.
