Figure 4: Case Study on CCLE/GDSC data.
From: High-dimensional genomic data bias correction and data integration using MANCIE
(a,b) Correlation between the CNV and RNA expression for gene NDUFC2. The expression data were using raw CCLE data (a) or MANCIE-adjusted with GDSC data (b). ρ refers to Spearman correlation coefficient. (c) Distribution of the correlation difference comparing before and after MANCIE adjustment, for all genes. The Spearman correlation coefficient between CNV and RNA expression was calculated for each gene, and the correlation difference is calculated by subtracting with MANCIE adjustment by without MANCIE adjustment. P value was calculated using the one-tail paired t-test. (d) Distribution of the correlation difference comparing comparing the raw data with SVA-adjusted expression data. P value was calculated using the one-tail paired t-test.
