Figure 1: Relationship between methylation values and oscillation of methylation (OM) for chromosome 1 of M1.
From: Information recovery from low coverage whole-genome bisulfite sequencing
(a) Patterns of oscillations as estimated by OM. Values were scaled to 0–1. (b) Relationship between methylation value and OM distribution in a representative region of M1. Delta (OM) values were scaled to 0–1. (c) Quantile distribution of OM values. Most oscillations are around 0, significant oscillations represent a deviation from the co-methylation and are used to call the successive COMET boundaries. (d) Rounded quantile distribution of OM values. COMETs are called using the dynamic OMg threshold which is defined by significant deviations in the OM distribution, representing roughly 8% of the OM values for the methylomes included here.
