Figure 3: Information recovery by DMC analysis.
From: Information recovery from low coverage whole-genome bisulfite sequencing
(a) Semi-quantitative DMP content recovery rates for DMR and DMC analysis based on the results from the RADmeth replicate analysis. DMP calls were set at P<0.05 after BH adjustment. DMRs are typically short compared to DMCs which accounts for the difference in DMP counts. (b) Example DMC (boxed red) showing methylation level (tracks 1–2), COMETs (tracks 3–5), DMPs (tracks 6–7), and DMRs (tracks 8–9) for M1 at maximum and 30X coverage, as well as M3. DMP calls are shown as adjusted p values for differential methylation between M1–2 and M7–10. DMR values representing differential methylation between M1–2 and M7–10 correspond to areaStat, a parameter of compound t-statistics for the included DMPs. COMET values correspond to the average value inside each block.
