Figure 8: FNDC4 knockout mice show increased inflammation and severity of DSS-induced colitis.
From: FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice
(a) Body weights of 12 week old mice, N=4. (b) Spleen weight, standardized to body weight at 16 weeks of age, N=4. (c) DAI (disease activity index). N=5 mice per group. *P<0.05, Mann–Whitney rank test. KO, Fndc4 knockout mice, WT, wild-type mice. (d) Colon length. **P<0.01, analysis of variance with Tukey’s post hoc test. (e) Body weight curve. *P<0.05 and q<0.05, Student’s T-test followed by the Benjamini-Hochberg false discovery rate correction. (f-g) Histopathology. Colitis severity assessment. N=11 mice per group, *P<0.05, Mann–Whitney rank test. (h) Gene expression, selected genes. *P<0.05; two-sided Student’s T-tests, N=5 mice per group. Disease severity was assessed blinded and the experiment was repeated with similar results. Mean±s.e.m.
