Figure 1: Overall structure of the human PRC2 complex.
From: Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
(a) Structure of the catalytically active core of PRC2 in cartoon representation. (b) Orthogonal view. (c) Stylized surface representation showing the relationship of the three lobes of PRC2. The N lobe consists of EED and the N-terminal region of EZH2. The middle lobe of the SUZ12 Vefs and EZH2 MCSS and SANT2. The catalytic lobe comprises the post SET and SET domains and a hairpin formed by the region of Suz12 N-terminal to the Vefs. Superposed is a cartoon indicating the activating Jarid2 peptide (yellow), which stabilizes the SRM region (pink), which in turn stabilizes the SET-I helix (blue) and thus completes the active site where substrate peptide (green) is bound. (d) Schematic representation of the domain architecture of PRC2 showing the composition of the complex. The distinct subdomains discussed in the main text and shown in a,b are indicated by the coloured regions.
