Figure 8: Mechanism of H2 relaxin binding to RXFP1.
From: The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1
(a) Cartoon model of the domain structure of RXFP1. (b) H2 relaxin interacts and binds to the linker and LRR domain of RXFP1. (c) Binding of H2 relaxin stabilizes and extends a helix within the linker to orient and enable interactions of the LDLa module and residues within the linker to exoloop-2 of the TMD to facilitate receptor activation. The TMD (blue), LRR domain (grey), LRR-LDLa linker (magenta) and LDLa module (cyan) of RXFP1 are indicated. Additional loops are coloured red with exoloop-2 (EL2) of the TMD annotated. H2 relaxin is coloured green.
