Figure 1: Genetic loss of RA synthesis does not affect Stra8 expression in fetal ovary. | Nature Communications

Figure 1: Genetic loss of RA synthesis does not affect Stra8 expression in fetal ovary.

From: Sex-specific timing of meiotic initiation is regulated by Cyp26b1 independent of retinoic acid signalling

Figure 1

Stra8 mRNA was detected in gonads by whole-mount in situ hybridization. (a–f) E13.5 ovary/mesonephros; (a) wild-type whole-mount, (b) wild-type vibratome section, (c) Raldh2−/− whole-mount, (d) Raldh2−/− vibratome section, (e) Raldh2−/−;Raldh3−/− whole-mount (f) Raldh2−/−;Raldh3−/− vibratome section. (g, h) E12.0 ovary/mesonephros. (i, j) E12.5 ovary/mesonephros. (k, l) E14.5 ovary/mesonephros. (m–o) E13.5 testis/mesonephros. Meso, mesonephros; ov, ovary; tes, testis. n=3 for all wild-type (WT) and Raldh2−/− (R2−/−) specimens; n=2 for all Raldh2−/−;Raldh3−/− (R2−/−;R3−/−) specimens; scale bar, 200 μm.

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