Figure 1: Distribution of all mutations across the cell cycle.
From: The topography of mutational processes in breast cancer genomes
Replication domains were identified by using conservatively defined transition zones in DNA replication time data. Data were separated into deciles, with each segment containing exactly 10% of the observed replication time signal. Normalized mutation density per decile is presented for early (left) to late (right) replication domains. (a) Aggregated distribution of mutations (green), rearrangements (purple) and indels (orange) across the cell cycle. (b) Distribution of the 12 base substitution signatures across the cell cycle. Dashed grey lines represent the predicted distribution of mutations for each signature based on simulations that take into account mutation burden and sequence characteristics of individual mutations and of the signatures that were estimated to be present in each patient (Methods section). (c) Distribution of the six rearrangement signatures across the cell cycle. Dashed grey lines represent the predicted distribution of mutations for each signature based on simulations. (d) Distribution of the indel signatures across the cell cycle.
