Figure 8: Genome-wide profiling of wt and St2−/− TAMs and survival correlation of IL-33 expression in grafted tumours. | Nature Communications

Figure 8: Genome-wide profiling of wt and St2−/− TAMs and survival correlation of IL-33 expression in grafted tumours.

From: The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages

Figure 8

(a) Heatmap of top 10 metastasis-related genes by genome-wide expression profiling of F4/80+ cells isolated from Panc02 tumours implanted in wt and St2−/− mice (n=3 samples per group). (b) Heatmap of top 10 up- and top 10 down-most cytokines, chemokines and their receptor genes by genome-wide expression profiling of F4/80+ cells isolated from Panc02 tumours implanted in wt and St2−/− mice (n=3 samples per group). (c) Schematic diagram shows in pericytes and stromal fibroblasts the PDGF-BB-PDGFRβ-IL-33-ST2 axis-recruited macrophages in switching a noninvasive tumour to a highly invasive tumour.

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