Figure 1: Variation in cancer cell line survival after radiation-induced damage. | Nature Communications

Figure 1: Variation in cancer cell line survival after radiation-induced damage.

From: A genetic basis for the variation in the vulnerability of cancer to DNA damage

Figure 1

(a) Distribution of cancer types profiled by lineage. (b) The high-throughput platform accurately profiles cancer cell lines. Integral survival was calculated for each cell line profiled by the high-throughput platform (n=1 (top), n=2 (bottom)) and by clonogenic survival measurements (n≥2). Scatter plots, linear regression, and R2 values were calculated comparing the integral survivals of the high-throughput platform to clonogenic survival. Data are expressed as the means±s.e.m. (c) Integral survival is displayed by column scatter plot separated by lineage and histology where appropriate. (d) Histogram, probability density function, and Normal Q–Q plots analyses of calculated integral survival of 533 cell lines (‘All’), 89 non-small cell lung cancer cell lines (‘NSCLC’), and 39 lung adenocarcinoma cell lines (‘LUAD’). (e) Correlation of response between radiation and compounds. Spearman correlation coefficient was calculated between integral survival values after exposure to radiation or 481 compounds. Correlation was then plotted relative to correlation rank. Some chemotherapeutic agents in clinical use are shown. HGG, high-grade glioma; LULC, lung large cell; LUSC, lung squamous cancer; PNET, primitive neuroectodermal tumours; SCLC, small cell lung cancer.

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