Figure 3: Ectopic expression of Arf significantly attenuates the tumourigenicity of Ms-iPSCs.
From: Tumour resistance in induced pluripotent stem cells derived from naked mole-rats
(a) Nude mice transplanted subcutaneously with Ms-iPSCs expressing red fluorescent protein (RFP; left) or Arf (right) 5 weeks after transplantation. Arrowhead: transplantation site. (b) Comparison of tumour weights 3 weeks after transplantation. Unpaired t-test; n=12 transplanted sites. The data are represented as mean±s.e.m. (c) Kaplan–Meier curve of tumour-free mice transplanted with Low-Arf-group Ms-iPSC clones (clone 5 and 6, n=8 mice, turquoise line), High-Arf-group Ms-iPSC clones (clone 2, 3 and 4, n=16 mice, blue line) or control Ms-iPSCs expressing RFP (n=8 mice, magenta line), respectively.
