Table 1 Summary of the interactions identified and validated for all viral proteins analysed.
Virus type/gene | Hit identification/technology | Hit validation/technology | Functional effect |
|---|---|---|---|
HAdV-A18/CR1α | SLAMF5/PM, SLAMF6/PM, SLAMF7/PM, IL-22/PM | SLAMF5/SPR, FC; SLAMF6/SPR, FC; SLAMF7/SPR, FC; IL-22/SPR | Increases SLAMF5 phosphorylation and inhibits T-cell activation in a SLAMF5-dependent manner |
HAdV-B55/CR1α | NH | — | — |
HAdV-D28/CR1α | LILRB2/FC | LILRB2/SPR | — |
HAdV-E4/CR1α | NH | — | — |
HAdV-F41/CR1α | NH | — | — |
HAdV-G52/CR1α | NH | — | — |
HAdV-A18/CR1β | SLAMF4/FC | SLAMF4/SPR | — |
HAdV-B55/CR1β | SLAMF6/PM | SLAMF6/SPR, FC | Increases SLAMF6 phosphorylation and inhibits T-cell activation |
HAdV-E4/CR1β | LILRB1/FC | LILRB1/SPR | Increases LILRB1 phosphorylation and inhibits NK cytotoxicity |
HAdV-F41/CR1β | SLAMF4/PM; TIM3/PM; LAIR-1/PM; LILRB2/FC | SLAMF4/SPR, FC; TIM3/SPR; LAIR-1/SPR; LILRB2/SPR, FC | — |
HAdV-G52/CR1β | NH | — | — |
HAdV-B1/CR1γ | SLAMF1/SPR; SLAMF3/SPR; SLAMF4/SPR; SLAMF7/SPR; SLAMF8/SPR | — | — |
HAdV-D30/CR1γ | NH | — | — |
HAdV-E4/CR1δ | NH | — | — |
HAdV-D9/CR1β | CD45/PM | CD45/SPR, FC | — |
HAdV-D19a/CR1β | CD45/PM; ISLR2/PM | CD45/SPR, FC; ISLR2/SPR, FC | — |
HAdV-D23/CR1β | CD45/PM | CD45/SPR, FC | — |
HAdV-D24/CR1β | CD45/PM; LILRB2/FC | CD45/SPR, FC; LILRB2/SPR | — |
HAdV-D28/CR1β | CD45/PM; PUNC/PM; CST3/PM; NELL2/PM; LILRB1/FC | CD45/SPR, FC; PUNC/SPR, FC; CST3/SPR; NELL2/SPR; LILRB1/SPR | — |
HAdV-D30/CR1β | CD45/PM; SLAMF3/PM; MPZL1/PM; IL-11/PM; DEFA3/PM; LILRB1/FC | CD45/SPR, FC; SLAMF3/SPR, FC; MPZL1/SPR, FC; IL-11/SPR; DEFA3/SPR; LILRB1/SPR | Increases SLAMF3 phosphorylation. Impairs SLAMF3-mediated cell adhesion. Increases MPZL1 activation and inhibits cell adhesion. Inhibits T-cell activation |
HAdV-D37/CR1β | CD45/PM; ISLR2/PM; LILRB2/FC | CD45/SPR, FC; ISLR2/SPR, FC; LILRB2/SPR | — |
HAdV-D39/CR1β | CD45/PM, LILRB1/PM | CD45/SPR, FC; LILRB1/SPR, FC | — |
HAdV-D43/CR1β | CD45/PM; EPHA3/PM; EPHA6/PM; LILRB1/FC | CD45/SPR, FC; EPHA3/SPR, IF; EPHA6/SPR; LILRB1/SPR | Modulates EPHA3/ephrin-A5 effect on cell adhesion |
HAdV-D47/CR1β | CD45/PM; CD300A/PM; CD300C/PM | CD45/SPR, FC; CD300A/SPR, FC; CD300C/SPR, FC | — |
HAdV-D51/CR1β | CD45/PM, LILRB1/PM | CD45/SPR, FC; LILRB1/SPR, FC | — |
HAdV-D53/CR1β | CD45/PM | CD45/SPR, FC | Inhibits NK cytotoxicity and T-cell activation |
HAdV-D58/CR1β | CD45/PM | CD45/SPR, FC | — |
