Table 1 Association of rs2238126 at 12p13.2 associated with colorectal cancer among individuals from eight Chinese study centres.

From: Common genetic variation in ETV6 is associated with colorectal cancer susceptibility

SNP

Allele *

Study group

Population

Sample size

Genotypes †

MAF ‡

OR (95% CI) §

P -value §

P het ||

I 2

    

Cases

Controls

Cases

Controls

Cases

Controls

    

rs2238126

A/G

GWAS

Nanjing-1

1,023

1,306

280/516/

227

304/629/373

0.526

0.474

1.25

(1.10–1.43)

7.41 × 10−4

  
  

Replication 1

Nanjing-2

855

1,258

228/425/

189

292/615/347

0.523

0.478

1.20

(1.06–1.36)

4.46 × 10−3

  
  

Replication 2

           
  

Replication

2a

Wuhan

805

1,200

206/399/

200

283/585/

332

0.504

0.480

1.10

(0.97–1.25)

0.137

  
  

Replication 2b

Guangzhou

1,179

1,334

300/620/

259

287/682/

365

0.517

0.471

1.26

(1.11–1.43)

2.57 × 10−4

  
  

Replication

2c

Nanjing-3

612

1,188

156/309/

147

293/584/

311

0.507

0.477

1.13

(0.98–1.29)

0.093

  
  

Replication

2d

Xi'an

643

384

164/325/

154

92/183/

109

0.508

0.478

1.13

(0.95–1.35)

0.180

  
  

Replication

2e

Hangzhou

511

647

146/246/

119

154/314/

179

0.526

0.481

1.19

(1.02–1.40)

0.032

  
  

Replication

2f

Shenyang

712

876

180/358/

174

200/443/

233

0.504

0.481

1.08

(0.93–1.25)

0.336

  
  

Replication

2

combined

 

4,462

5,629

  

0.511

0.477

1.15

(1.08–1.21)

2.72 × 10−6

0.590

0

  

All

combined

 

6,340

8,193

  

0.515

0.477

1.17

(1.11–1.23)

2.67 × 10−10

0.626

0

  1. CI, confidence interval; GWAS, genome-wide association study; MAF, minor allele frequency; OR, odds ratio; SNP, single-nucleotide polymorphism.
  2. *Major/minor allele.
  3. †The distribution of GG, GA and AA genotypes.
  4. MAF of G allele.
  5. §OR, 95% CI and the corresponding P-values were derived from logistic regression analysis under an additive model with adjustment for top eigen, age and sex, where appropriate.
  6. ||P value for the heterogeneity.
  7. GWAS and replication stages were combined by meta-analysis under a fixed-effects model.
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