Table 2 Association of colorectal cancer risk with rs2238126 at 12p13.2 in individuals of European and Asian populations combined.

From: Common genetic variation in ETV6 is associated with colorectal cancer susceptibility

SNP

Allele *

Study

Population

Sample size

MAF †

OR (95% CI) ‡

P -value ‡

    

Cases

Controls

Cases

Controls

  

rs2238126

A/G

OFCCR

European

1,046

1,076

0.179

0.155

1.19 (1.01–2.12)

0.034

  

This study

Asian

6,340

8,193

0.515

0.477

1.17 (1.11–1.23)

2.67 × 10−10

  

Meta-analysis§

     

1.17 (1.12–1.23)

2.79 × 10−11

  1. CI, confidence interval; GWAS, genome-wide association study; MAF, minor allele frequency; OFCCR, ontario registry for studies of familial colorectal cancer; OR, odds ratio; SNP, single-nucleotide polymorphism.
  2. *Major/minor allele.
  3. †MAF of G allele.
  4. Additive model.
  5. §Results were combined by meta-analysis using a fixed-effects model (Pheterogeneity=0.853, I2=0).
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