Table 1 Properties of mechanotransduction and general electrophysiology in hair cells from organoids, utricles and values from the literature.
ES cell-derived organoid | Utricle P4 | Utricle (Literature) | |
|---|---|---|---|
Transduction amplitude D24–27 (pA) | 144±18 (13) | 136±20 (7) | 155±16 (36) (ref. 24) |
164±76 (8) (ref. 16) | |||
Transduction 10–90% range (μm) | 1.6±0.1 (12) | 1.2±0.1 (7) | 1.3±0.4 (8) (ref. 16) |
Transduction adaptation τfast (ms) | 9.1±1.6 (7) | 7.6±2.3 (6) | ∼3 (15) (ref. 26) |
5.2±0.7 (ref. 24) | |||
Transduction adaptation τslow (ms) | 83.4±8.7 (7) | 62.3±6.2 (6) | ∼50 (13) (ref. 26) |
49±37 (8) (ref. 16) | |||
49±6 (9) (ref. 27) | |||
45.6±4.5 (41) (ref. 24) | |||
Transduction extent of adaptation (%) | 44.5±5.0 (7) | 66.3±5.4 (7) | ∼65% (17) (ref. 26) |
65±3 (ref. 25) | |||
Resting potential Type II (mV) | −63.2±0.7 (38) | −58.2±0.8 (6) | −64±5.2 (98) (ref. 58) |
Resting potential Type I (mV) | −79.3±1.6 (4) | −78.1, −86.0 (2) | −77.2±3.1 (62) (ref. 58) |
P5+2DIC | |||
Input resistance Type II (MΩ) | 1,228.7±119.9 (22) | 934±85 (12) | 1,390±830 (98) (ref. 17) |
Input resistance Type I (MΩ) | 49.7±11.2 (5) | 57.7±14.8 (4) | 55±41 MΩ (28) (ref. 17) |
P5+2DIC through P9 | |||
Capacitance (pF) | 6.0±0.2 (136) | 4.8±0.2 (11) | 5.0±1.3 (16) (ref. 17) |
Type II |
