Figure 6: CatSperδ-null mice lack CatSper current.
From: A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa
(a) CatSperδ-het and (b) CatSperδ-null ICatSper. The upper traces show representative time courses of ICatSper measured in control solutions (1), nominally divalent-free (DVF) solutions (2), and high-K+ solutions (3) at −100 mV (blue circles) and +100 mV (black circles). Bottom panels show the current–voltage relations of monovalent ICatSper in response to voltage ramps at the time points indicated. ICatSper is absent in CatSperδ-null sperm cells. A small inward IKSper was seen in both phenotypes when the bath solution was switched to 160 mM K-MeSO3. CatSperδ-het currents are indistinguishable from previously published wt currents1.
