Table 1 Synaptic plasticity at CA3–CA3 recurrent synapses.

From: Symmetric spike timing-dependent plasticity at CA3–CA3 synapses optimizes storage and recall in autoassociative networks

Basic properties of compound EPSPs at CA3–CA3 recurrent synapses (n=42)

Value

Peak EPSP (mV)

2.5±0.2

Latency (ms)

2.7±0.1

20–80% Rise time (ms)

4.9±0.2

Decay time constant (ms)

103.7±4.2

Condition

Value (% of baseline)

Number of cells, n

P

LTP induced by HFS *

 HFS control

196.8±18.4

14

0.0002†

 HFS+D-AP5 (20 μM, bath application)

98.7±11.0

6

0.0007, 0.002‡

 HFS+EGTA (20 mM, intracellular)

102.4±11.2

5

0.0007, 0.006‡

 HFS+nimodipine (10 μM, bath application)

82.0±8.0

5

0.0007, 0.001‡

LTP induced by pairing of pre- and postsynaptic activity §

 STDP (+10 ms) control

178.0±22.1

9

0.004†

 STDP (+10 ms) D-AP5 (20 μM, bath application)

101.2±5.2

7

0.0007, 0.03‡

 STDP (+10 ms) EGTA (20 mM, intracellular)

101.8±7.2

8

0.0007, 0.02‡

 STDP (+10 ms) nimodipine (10 μM, bath application)

91.1±6.0

5

0.0007, 0.04‡

 STDP (–10 ms) control

159.3±11.5

17

0.00002†

 STDP (–10 ms) D-AP5 (20 μM, bath application)

100.5±4.2

6

0.0005, 0.001‡

 STDP (–10 ms) EGTA (20 mM, intracellular)

103.0±9.0

6

0.0005, 0.01‡

 STDP (–10 ms) nimodipine (10 μM, bath application)

105.0±6.1

5

0.0005, 0.01‡

 Presynaptic stimulation only

102.8±2.9

6

0.31†

 Postsynaptic APs only

95.7±4.4

6

0.38†

 STDP (–10 ms) with hyperpolarizing current pulse

114.6±13.0

9

0.03||, 0.22†

  1. AP, action potential; D-AP5, D-2-amino-5-phosphonovaleric acid; EGTA, ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid; HFS, high-frequency stimulation; EPSP, excitatory postsynaptic potential; LTP, long-term potentiation; STDP, spike timing-dependent plasticity.
  2. All data presented in table were obtained at room temperature. For details, see the text.
  3. *The HFS protocol consisted of 4 trains of 100 stimuli at 100 Hz delivered every 10 s.
  4. †Significance was tested using Wilcoxon signed rank test (control versus test period after induction).
  5. ‡Significance was assessed using Kruskal–Wallis test, followed by Wilcoxon–Mann–Whitney two-sample rank test (control versus experimental manipulation), using Bonferroni correction for multiple comparisons.
  6. §The pairing protocol consisted of 300 repetitions of a single presynaptic stimulation paired with a postsynaptic AP at different time intervals at 1 Hz.
  7. ||Significance was assessed using Wilcoxon–Mann–Whitney two-sample rank test (control versus experimental manipulation).
Back to article page