Figure 5: In vitro IC₅₀ response of pfmdr1-modified and parental lines.

IC₅₀ values (nM) are presented for CQ, md-CQ, md-ADQ and QN. Five to ten assays were performed for each drug (Supplementary Tables 3 and 4). Statistical evaluations comparing mutant pfmdr1-modified lines against recombinant control lines of the same genetic backgrounds were performed using two-tailed Mann–Whitney U-tests, as described for Fig. 4. *P<0.05, **P<0.01 and ***P<0.001.