Figure 2: Key experiments and reaction discovery.
From: A two-step approach to achieve secondary amide transamidation enabled by nickel catalysis
Failed reaction using substrate 8a in the absence of catalyst/ligands or activating group (entries 1 and 2), initial promising result (entry 3) and optimized reaction conditions (entry 4). For entries 1–3, yields shown were determined by 1H NMR analysis with an internal standard. For entry 4, the yield shown reflects the average of two isolation experiments.
