Figure 3: Scope of methodology.
From: A two-step approach to achieve secondary amide transamidation enabled by nickel catalysis
The scope of the transamidation methodology was evaluated with respect to the Boc-activated amide substrate (entries 1–10), and with respect to the amine nucleophile using 8b (entries 11–18). Reactions were carried out using Ni(cod)2 (5–10 mol%), SIPr (10–20 mol%), substrate (1.00 equiv), amine (1.5–2.5 equiv) and toluene (1.0 M) at 35–60 °C for 14 h. Yields shown reflect the average of two isolation experiments.
