Figure 4: Epistasis and the evolution of alternative splicing.
From: The complete local genotype–phenotype landscape for the alternative splicing of a human exon
(a,b) Distribution of the number of epistatic interactions with near-neutral mutations for near-neutral (A, N × N network) or all (B, N × X network) mutations. (c) Visualization of positive (orange) and negative (green) epistatic interactions between near-neutral mutations and any other mutation. The number of near-neutral mutations at each site is depicted by different shades of grey (light=1 near-neutral mutation at the site; intermediate=2; dark=3). (d) Linear distance between epistatically and non-epistatically interacting pairs of mutations for the N × N and N × X networks. (e) Effect of all single mutations (columns) in near-neutral backgrounds (rows). Rows and columns are ordered by the effect of the mutation in the wt background (as represented by the horizontal and vertical scales).
