Figure 5: Example CG simulation data under fixed molecular crowding.
From: Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly
(a) ‘Available’ assembly-competent CA in solution for initial [CA]+=0.5 mM (resulting in no nucleation and growth of mature lattice) and initial [CA]+=1.0 mM (producing nucleation and growth of a single-lattice region, see the main text and Table 2). Lattice growth continues below the level of available [CA]+ required for nucleation on the same timescale. (b) Number of separate lattice regions containing key structural motifs for [CA]+=1 mM. The number of trimers in solution (blue curve) reduces significantly as a single region of lattice grows.
