Figure 5: Clonal heterogeneity of ESR1 mutations. | Nature Communications

Figure 5: Clonal heterogeneity of ESR1 mutations.

From: Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant

Figure 5

Dynamic changes in ctDNA mutation AF changes for six patients while on treatment as examples of clonal heterogeneity of ESR1 mutations. Each line represents a different ESR1 or PIK3CA mutation, and raw AF values are plotted for each time point. Patients 2310 and 6951 demonstrate divergent behaviour of mutations. Patients 4956, 4251, 6152 and 1653 demonstrate consistent increases and/or decreases of AF.

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