Figure 5: Global mRNA expression in marker-positive human prostate tumour cells.
From: Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling
(a) Venn-diagram of genes differentially expressed in prospectively isolated CWR22 OT-tumour cells with low (expressing EpCAM, CD44 or α2-integrin), moderate (expressing TRA-1-60, CD151 or CD166) and high (triple-marker-positives) sphere/tumour-forming efficiencies (S/TFE). Gene expression data in β4-integrin-positive (no sphere-forming) cells and the total tumour cells were used as baseline expression control. (b) Fold enrichment of gene ontology based functional categories in all the S/TFE data sets. (c–f) Catalogue of top differentially expressed genes: (c) shared among all the above three data sets, (d) shared between moderate and high S/TFE data sets, (e) expressed specifically in moderate S/TFE data set and (f) expressed specifically in high S/TFE data set.
