Figure 2: MAIT cell activation during chronic viral infection in vivo.
From: MAIT cells are activated during human viral infections
PBMC’s from healthy controls (n=20–23) or patients (n=12–25) with persistent (treatment naive, REL, NR) and resolved HCV infection (SVR, SC) were analysed by flow cytometry by gating on live CD3+CD8+CD161++Vα7.2+ (MAIT) cells. (a) MAIT cell frequency as a proportion of the CD8+ T cells. (b,c) Granzyme B expression by MAIT cells. (b) Representative flow cytometry plots. Bars represent means±s.e.m. Statistical significance was determined with the Kruskal–Wallis test followed by the Dunns’ test. ns>0.05, *P 0.05, **P≤0.01, ***P≤0.001, ****P≤0.0001. HC, healthy control; Gr B, Granzyme B; REL/NR, relapse/non-response; SC, spontaneous clearance; SVR, sustained virological response; tr., treatment.
