Table 1 In cases where identical epitopes are targeted by multiple individuals, escape occurs more rapidly when the fitness cost of escape is lower.

From: Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable

Epitope

Patient

HLA restriction

Fitness cost ΔE

Escape time (days)

TPQDLNTML (TL9)

CH185

B*81:01

4.3

122

 

CH159

B*81:01

6.1

>1,103*

TSTLQEQVAW (TW10)

CAP239

B*58:01

−1.4

1

 

CH198

B*57:03

0.1

220

WHLGHGVSI (WI9)

CAP210

B*15:10

2.8

127

 

CAP45

B*15:10

4.7

408†

EEVGFPVRPQV (EV11)

CH164

B*45:01

2.6

31

 

CAP45

B*45:01

4.0

43

  1. *No escape observed (final sequencing time).
  2. †Antigen-processing escape.
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