Figure 8: Proposed model for the function of BRAT1 and BRP1 in DNA demethylation and anti-silencing. | Nature Communications

Figure 8: Proposed model for the function of BRAT1 and BRP1 in DNA demethylation and anti-silencing.

From: The Arabidopsis acetylated histone-binding protein BRAT1 forms a complex with BRP1 and prevents transcriptional silencing

Figure 8

MBD7 binds to methylated genomic regions and recruits the histone acetyltransferase IDM1 to chromatin, thereby mediating histone acetylation at methylated genomic regions. BRAT1 binds to acetylated histones through its bromodomain and associates with an ATPase domain-containing protein, BRP1 to form a complex. The BRAT1–BRP1 complex may act to facilitate active DNA demethylation by ROS1 and also prevent transcriptional silencing at hypermethylated genomic regions in a DNA demethylation-independent manner.

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