Figure 2: Tissues bearing cells with hyper-long telomeres are healthy. | Nature Communications

Figure 2: Tissues bearing cells with hyper-long telomeres are healthy.

From: Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations

Figure 2

(a) Micrographs show histology of intestine, skin and brain from chimaeric mice bearing cells with normal telomere length and other cells with hyper-long telomeres (GFP-positive). Note that tissues containing GFP-positive cells are healthy. Scale bar, 50 μm. (b) The graphs show the percentage of GFP-positive cells found in intestine, brain and skin of chimaeric mice bearing hyper-long telomeres, over the period of time indicated. (c) The scheme shows how chimaeric mice were generated. (d) Per cent of GFP-positive cells in blood from chimaeric mice bearing hyper-long telomeres during the period of time is indicated. (e) Scheme shows that the chimaeric mice analysed were constituted by two different backgrounds, 129S1 with hyper-long telomeres and CD1 cells with normal length telomeres. (f) Graphs show mean telomere length in intestine, skin and brain in newborns and 6 months chimaeric mice compared with aged-matched animals from the 129S1 and CD1 backgrounds. Representative graph of two independent experiments. The s.e.m. was represented in error bars. Student t-test with the Bonferroni correction was used to calculate the P values. E&H, eosin and haematoxylin.

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