Figure 1: Multidimensional scaling plot for the correlation of highly mutated genes.
From: A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC
This plot (Euclidean distance model) graphically depicts the correlation of the 17 genes, with elevated non-silent mutation rates presented in Table 2 along with MSI-H status and presence of distant metastasis (D-meta). The most significant correlated genes BRAF, APC, KRAS, TP53 and MSI-H and D-meta are highlighted in red. BRAF is very close to (having strong positive correlation with) MSI-H but is anticorrelated with (far apart from) distant metastasis. Conversely, the partnering mutations (APC, KRAS and TP53) are comparatively close to each other and are with distant metastasis. Notably, ITGB4, CSMD3 and CBX4 are much closer to MSI-H than D-meta on the plot. FAM123B, also called AMER1, is a chromosome X-linked mutation, and 38/51 patients with mutations are female.
