Table 4 Five classes grouped by the APC mutation status with partnering mutations.

From: A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC

Classes

Age

%Right

%MSI

%Mets

% Stage

Devel_Mets

 

N

Median

   

1–2

3

4

 

0 ‘APCwt’

156

70

53

29

29

49

29

21

8

1* ‘A(1), A(1)K, A(1)P’

142

64

28

5

37

42

32

24

13

2† ‘A(2), A(2)K, A(2)P’

84

65

37

10

25

50

27

21

4

3 ‘APC(1)KP’

45

63

40

0

51

31

40

27

24

4§ ‘APC(2)KP’

41

66

51

2

51

15

54

32

20

Trend p-value

468

 

0.090

<0.0001

0.015

 

0.009

 

0.031

  1. APC, Adenomatous polyposis coli; Mets, metastasis; MSI, microsatellite instability.
  2. (1)* A−APC, K−KRAS, P−TP53.
  3. Class 0: APC wild type; Class 1: APC(1), APC(1)/KRAS, APC(1)/TP53; Class 2: APC(2), APC(2)/KRAS, APC(2)/TP53; Class 3: APC(1)/KRAS/TP53; Class 4: APC(2)/KRAS/TP53.
  4. While A(1) or APC (1) represents one APC mutation, A(2) or APC (2) represents two APC mutations.
  5. (2)† There is significantly higher or lower observation than expectation: () for P<0.05; () for P<0.01; () for P<0.001, based on individual χ2 contribution from the table cell.
  6. (3) Devel_Mets for the patient who was initially diagnosed with primary cancer (not stage 4) and developed Mets after that.
  7. (4)§ A significantly higher (than expectation) rate of MSI was observed in Class 0 (χ2, P<0.001), while the lower rate was associated with one APC-mutation tumour (Class 1, χ2, P<0.01 and Class 3, χ2, P<0.05). Class 4 tumours were significantly associated more with stage 3 (χ2, P<0.05) and less with stage 1–2 tumours (χ2, P<0.01). However, a higher rate of ‘developing’ metastasis (Devel_Mets) was demonstrated for Class 3 (χ2, P<0.01).
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