Table 5 Cox model predictors of overall survival of MSS tumours (N=407).
From: A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC
Covariable | N | Model 1 | Model 2 | Model 3 | Model 4 | ||||
|---|---|---|---|---|---|---|---|---|---|
HR | P -value | HR | P -value | HR | P -value | HR | P -value | ||
APC | 296 | 0.65 | 0.021 | 0.56 | 0.008 | 0.49 | 0.001 | 0.59 | 0.006 |
KRAS | 179 | 1.62 | 0.007 | ||||||
TP53 | 261 | 1.41 | 0.056 | ||||||
BRAF | 18 | 2.63 | 0.002 | 2.38 | 0.005 | 2.23 | 0.011 | 2.25 | 0.011 |
AKP | 85 | 1.79 | 0.005 | 1.43 | 0.090 | ||||
Two APC mut | 116 | 1.29 | 0.217 | 1.58 | 0.027 | ||||
APC(2)KP | 40 | 2.10 | 0.003 | ||||||
Metastasis | 155 | 4.55 | <0.0001 | 4.49 | <0.0001 | ||||
Age (⩾70) | 131 | 1.05 | 0.005 | 1.04 | 0.008 | 1.09 | <0.0001 | 1.09 | <0.0001 |
LR χ2 | 407 | 29.7 | <0.0001 | 28.9 | <0.0001 | 98.5 | <0.0001 | 97.9 | <0.0001 |
