Figure 5: RepID-deficient MEFs exhibit replication fork asymmetry. | Nature Communications

Figure 5: RepID-deficient MEFs exhibit replication fork asymmetry.

From: A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells

Figure 5

(a) Examples of DNA fibres derived from wild-type and RepID −/− MEFs that contain symmetric and asymmetric replication forks. (b,c) Scatter plots of left and right fork lengths in RepID WT (b) and RepID −/− (c) cells. The percentages of the asymmetric forks (outside the red lines) and the number of replication forks measured in both cells are presented on the plots, demonstrating that 31% of forks were asymmetric in RepID−/− MEFs, whereas 8% of forks were asymmetric in RepID WT MEFs.

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