Figure 2: Brain-specific Crmp2 knockout mice display schizophrenia-related behaviours. | Nature Communications

Figure 2: Brain-specific Crmp2 knockout mice display schizophrenia-related behaviours.

From: Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice

Figure 2

(a–c) Summary plots of total distance in the open-field test (a), home-cage activity (b) and prepulse inhibition (c). (d–f) cKOs display social withdrawal as shown by lower nest scores in the nest building test (d), less time spent in the chamber containing the social partner (S1) and more time in the chamber containing the empty cage (E) in the social interaction test (e), and reduced preference for the novel social partner (S2) and increased time spent in the chamber with familiar social partner S1 in the social novelty test (f). (g–j) cKOs display impaired hippocampal-dependent learning and memory deficits as shown in the Y maze test (g) in the fear conditioning test (h) and in the Morris water maze test (j). Values represent mean±s.e.m. (*P<0.05, **P<0.01, ***P<0.001; c,e,f,i: one-way ANOVA with Tukey post hoc test; all others: unpaired t-test). Numbers of animals used in each test are indicated in each bar graph or as indicated.

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