Figure 8: WSB1 is present in Lewy bodies in human PD post-mortem brain tissue.
From: Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1
(a) PD post-mortem tissue from the substantia nigra, showing WSB1 co-localizes with the Lewy body markers, alpha-synuclein and ubiquitin in Lewy bodies. (b) PD post-mortem tissue from the substantia nigra, showing WSB1 co-localizes with alpha-synuclein and ubiquitin in Lewy neurites. (c) LRRK2 and WSB1 also co-localize in Lewy bodies. This suggests a role for WSB1 in sporadic PD, as well as LRRK2 PD. Scale bars, 10 μm.
