Figure 4: Metformin and PolyMet inhibit H460 tumour growth.
From: PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery
PBS, Metformin, LPH-PEI and LPH-PolyMet were administered i.v. every other day, and mice were killed 24 h after the final injection. (a) Tumour volumes were measured every day. (b) Tumour weights were measured on day after final injection and compared with body weights to determine the percentage of tumour burden. (c) Visual observations of the H460 tumour sizes in each treatment group at the end time point; Data are mean±s.e.m. (n=5 per group) analysed by two-way analysis of variance with Tukey’s correction. Data are combined from a and b or representative of (c) three independent experiments. NS, not significant; *P<0.05, **P<0.01, ***P<0.005.
