Figure 1: Unbiased clustering of a combinatory set of 30 RA and 16 OA.

(a) Hierarchical clustering separated RA and OA into two groups (with three possible outliers: RA_11, OA_14 and OA_15). The FLS origins from knee and hip were labelled with purple circle and cyan square, respectively. The other unlabelled samples include FLS from other joints or where the source was unknown. (see Supplementary Table 3 for details). (b) PCA also divided RA and OA with the three possible outliers (arrows) at the edge of separation, indicating that these FLS lines were within the margins for their respective disease.